Description
Scientist - Vitro Biopharmaceutics/Validation/Beerse, Belgium/12 Months Contract/30 EUR (Per Hour)
As a Scientist, your overall mission is to design, validate and implement automated high output workflows in the Janssen R&D biopharmaceutical platform. You will focus on scientific innovations to strengthen our knowledge of the biopharmaceutical properties of the drug substance and drug product, ensuring optimal in vivo performance.
Your Function
- Implementation of (semi-)automated high-output in vitro workflows in the Janssen R&D biopharmaceutical platform to understand and predict the gastro-intestinal absorption potential of new compounds across stages of development.
- Design, coordinate, execute and report experimental work related to Biopharmaceutics and Physiology Based Pharmacokinetic (PBPK) modelling in support of drug product development.
- Continuously improve existing workflows based on in silico needs and in vivo performance.
- Participate in the evaluation of new analytical techniques in the area of biorelevant testing and keep up to date with scientific innovations.
- Build and maintain strong relationship with key stakeholders including Discovery Sciences, Clinical Pharmacology, Drug Product Development and Analytical Development.
- Work in a multidisciplinary team of researchers, internally as well as externally.
Non Technical Skills and Additional Details
- Master or Doctorate (Ph.D.) in Biopharmaceutics, Pharmaceutical Sciences, Biology, Engineering or related science with relevant experience in biopharmaceutics.
- Hands on experience with preformulation/biopharmacy related in vitro techniques (eg solubility, dissolution, precipitation, solid state characterization, permeability).
- Knowledge of and strong interest in API physico-chemistry, solid state, drug absorption principles, formulation optimization, pharmacokinetics and mechanistic design.
- Like to work in the lab and able to perform experiments in state-of-the-art laboratories including using automated platforms
- Highly motivated, with excellent organizational, interpersonal, communication, and collaborative skills.
- Fluent English (both spoken and written) with excellent scientific writing skills.
- Team player, dynamic, stress resistant, innovative and flexible. Assets
- Strong interest in working with down scaled and automated high-throughput experimentation and characterization platforms
- Understanding of the concepts behind PBPK modelling (Gastroplus/Simcyp) and in vitro biopharmaceutics (eg solubility, biorelevant dissolution, particle characterization, solid state characteristics).
The Company
Johnson & Johnson is an American multinational medical devices, pharmaceutical and consumer packaged goods manufacturer founded in 1886.
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